Chimeric histone acetyltransferase polypeptides

Details Chimeric histone acetyltransferase polypeptides Chimeric histone acetyltransferase polypeptides

C - Chemistry, Metallurgy

07

K

C07K 1/00 (2006.01) A01K 67/00 (2006.01) A01K 67/033 (2006.01) C07K 14/00 (2006.01) C07K 17/00 (2006.01) C12N 9/10 (2006.01) C12N 9/14 (2006.01) C12N 9/16 (2006.01) C12N 15/63 (2006.01) C12N 15/82 (2006.01) C12N 15/85 (2006.01) C12N 15/87 (2006.01) C12Q 1/00 (2006.01) G01N 33/00 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2451654

Chimeric polypeptides are disclosed that comprise a first polypeptide segment having histone acetyltransferase enzymatic activity and a second polypeptide segment that is similar to a subunit of a chromatin-associated histone deacetyltransferase protein complex. Also disclosed are nucleic acids encoding such chimeric polypeptides and eukaryotic organisms expressing such chimeric polypeptides.

La présente invention concerne des polypeptides chimériques qui comprennent un premier segment de polypeptide présentant une activité enzymatique d'histone acétyltransférase et un second segment de polypeptide qui est similaire à une sous-unité d'un complexe protéique d'histone déacétyltransférase associé à la chromatine. L'invention concerne également des acides nucléiques codant lesdits polypeptides chimériques et des organismes eucaryotes exprimant lesdits polypeptides eucaryotes.

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