Chimeric human papillomavirus (hpv) l1 molecules and uses...

Details Chimeric human papillomavirus (hpv) l1 molecules and uses... Chimeric human papillomavirus (hpv) l1 molecules and uses...

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 39/00 (2006.01) C07K 14/025 (2006.01) C07K 16/08 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12P 21/06 (2006.01)

Patent

CA 2411945

Disclosed are chimeric HPV L1 proteins and virus like particles comprising the same which are capable of generating high titer neutralizing antibody responses against at least two HPV types. The disclosed chimeric HPV L1 proteins and VLPs are useful as therapeutic and prophylactic reagents, as well as reagents for diagnosing papillomavirus infection.

La présente invention concerne des protéines chimériques HPV L1 et des particules de type viral comprenant ces protéines qui peuvent générer des réponses d'anticorps neutralisant à titre élevé dirigés contre au moins deux types de papillomavirus. Ces protéines chimériques HPV L1 et ces particules de type viral conviennent comme réactifs thérapeutiques et prophylactiques, et comme réactifs permettant de diagnostiquer une infection par papillomavirus.

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