Chimeric, hybrid and tandem polypeptides of meningococcal...

Details Chimeric, hybrid and tandem polypeptides of meningococcal... Chimeric, hybrid and tandem polypeptides of meningococcal...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/22 (2006.01)

Patent

CA 2630929

NMB 1870 is a protein in Neisseria meningitidis. Three families of NMB 1870 are known. To increase the ability of a NMB 1870 protein to elicit antibodies that are cross-reactive between the families, NMB 1870 is engineered. Sequences can be substituted from one NMB 1870 family into the corresponding position in another family. Proteins of NMB 1870 sequences from different families can be joined to each other.

L~invention porte sur une protéine NMB 1870 de Neisseria meningitidis. Trois familles NMB 1870 sont connues. Pour augmenter la capacité d'une protéine NMB 1870 de provoquer des anticorps qui interagissent entre les familles, on construit une NMB 1870. Les séquences peuvent être substituées d'une famille de NMB 1870 dans la position correspondante d~une autre famille. Des séquences de protéines NMB 1870 venant de familles différentes peuvent être jointes les unes aux autres.

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