C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/04 (2006.01) A61K 39/104 (2006.01) A61K 39/12 (2006.01) A61K 48/00 (2006.01) C07K 14/025 (2006.01) C07K 14/21 (2006.01) C07K 14/35 (2006.01) C07K 14/475 (2006.01) C07K 14/535 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/27 (2006.01) C12N 15/31 (2006.01) C12N 15/37 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2388045
The invention provides chimeric nucleic acids encoding a chimeric polypeptide, constructs for expressing these polypeptides both in vitro and in vivo, isolated chimeric polypeptides, pharmaceutical compositions and methods of making and using these compositions. These compositions and methods are particularly useful for stimulating or enhancing the immunogenicity of a selected antigen or stimulating or enhancing a cellular immune response specific for that antigen. The nucleic acid of the invention comprises a first polypeptide domain comprising a carboxy terminal fragment of a heat shock protein (HSP), an Flt-3 ligand (FL), a cytoplasmic translocation domain of a Pseudomonas exotoxin A (ETA dII), or a granulocyte-macrophage-colony stimulating factor (GM-CSF) sequence, and a second polypeptide domain comprising an antigenic polypeptide.
La présente invention concerne des acides nucléiques nouveaux codant pour un polypeptide chimérique, des constructions pour l'expression desdits polypeptides <i>in vitro</i> et <i>in vivo</i>, des polypeptides chimériques isolés, des compositions pharmaceutiques et des procédés de fabrication desdites compositions. Lesdits compositions et procédés sont notamment utiles pour favoriser ou améliorer l'immunogénicité d'un antigène sélectionné ou pour favoriser ou améliorer la réponse cellulaire immunitaire audit antigène. L'acide nucléique selon l'invention comporte un premier domaine polypeptidique comprenant un fragment de terminal carboxy d'une protéine de choc thermique (HSP), un ligand Flt (FL), un domaine de translocation cytoplasmique d'une étotoxine A de <i>Pseudomonas</i> (ETAdII) ou une séquence du facteur de stimulation de granulocytes et macrophages (GM-CSF), et un deuxième domaine polypeptidique comprenant un polypeptide antigénique.
Hung Chien-Fu
Wu Tzyy-Choou
Johns Hopkins University
Smart & Biggar
LandOfFree
Chimeric immunogenic compositions and nucleic acids encoding... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric immunogenic compositions and nucleic acids encoding..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric immunogenic compositions and nucleic acids encoding... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1623638