Chimeric immunogens

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 39/155 (2006.01) A61K 39/295 (2006.01) A61K 48/00 (2006.01) C07K 14/115 (2006.01) C07K 14/135 (2006.01) C07K 19/00 (2006.01) C12N 15/45 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2126863

Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.

Des gènes hybrides multimères, codant la protéine chimérique correspondante, comprennent une séquence génique codant une région antigénique d'une protéine provenant d'un premier pathogène, liée à une séquence génique codant une région antigénique d'une protéine provenant d'un second pathogène. En particulier, les pathogènes sont le virus à parainfluenza (PIV) et le virus respiratoire syncytial (RSV). Un immunogène recombiné unique est capable de protéger les nourrissons ainsi que des personnes présentant une sensibilité analogue, contre les maladies provoquées à la fois par le PIV et le RSV.

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