Chimeric influenza virus-like particles comprising...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/11 (2006.01) A01H 5/00 (2006.01) A61K 39/145 (2006.01) A61P 31/16 (2006.01) C07K 19/00 (2006.01) C12N 7/00 (2006.01) C12N 7/01 (2006.01) C12N 15/44 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2762042

A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

L'invention concerne un procédé de synthèse de particules de type virus (VLP) de la grippe chimériques dans une plante ou une partie de plante. Le procédé entraîne l'expression de HA de grippe chimérique dans une plante ou une partie de plante. L'invention concerne également une VLP qui comporte une protéine HA de grippe chimérique et des lipides végétaux. L'invention concerne également un acide nucléique codant pour HA de grippe chimérique ainsi que des vecteurs. Les VLP peuvent être utilisés pour formuler des vaccins contre la grippe, ou peuvent être utilisés pour enrichir les vaccins existants.

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