Chimeric mammals with human hematopoietic cells

Details Chimeric mammals with human hematopoietic cells Chimeric mammals with human hematopoietic cells

C - Chemistry, Metallurgy

12

N

C12N 5/12 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A61K 35/28 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2122725

2122725 9309792 PCTABS00022 There is disclosed a chimeric mammal having a stable bone marrow graft of human hematopoietic cells capable of differentiating into multiple lineages of human mature cells, wherein at least 30 % of the hematopoietic cells in the mammal's bone marrow are of human origin. The inventive method comprises sublethally irradiating an immunodeficient mammal, infusing human hematopoietic cells into the mammal and administering an effective amount of human mast cell growth factor (MGF) and a human granulocyte macrophage colony stimulating factor/interleukin-3 fusion protein (GM-CSF/IL-3 FP) to promote engraftment of human cells within the chimeric mammal's bone marrow.

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