Chimeric mhc class i antigens for inducing allograft tolerance

Details Chimeric mhc class i antigens for inducing allograft tolerance Chimeric mhc class i antigens for inducing allograft tolerance

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) C07K 14/74 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2190576

Chimeric MHC Classe I molecules having a recipient-type N-terminus, a donor-type alpha-1 helical region, and a recipient-type alpha-2 domain induce tolerance to donor grafts when administered to the recipient at time of transplantation.

Des molécules chimères de classe I du complexe majeur d'histocompatibilité présentant une extrémité N-terminale de type receveur, une région hélicoïdale alpha-1 de type donneur, et un domaine alpha-2 de type receveur induisent une tolérance à des greffes de donneurs lorsqu'on les administre aux receveurs au moment de la transplantation.

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