Chimeric molecules containing a module able to target...

Details Chimeric molecules containing a module able to target... Chimeric molecules containing a module able to target...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07K 16/30 (2006.01) C12N 5/00 (2006.01) C12N 5/16 (2006.01) C12N 15/62 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2436281

A chimeric polypeptide has the formula: pTox-pTarg, wherein pTox is a viral apoptotic peptide, such as the Vpr peptide of HIV-1 or a fragment of the Vpr peptide of HIV-1 containing the amino acid motif H(F/S)RIG that interacts with mitochondrial inner membrane, adenine nucleotide translocation (ANT) protein of a cell. pTarg is an antibody or an antibody fragment that binds to the outer membrane of the cell. Binding of the chimeric polypeptide to the cell is followed by apoptosis of the cell. A vector encoding a chimeric polypeptide and a recombinant host cell comprising the vector are provided. The chimeric polypeptide us useful for targeting pTox to cells, such as cancer cells.

L'invention concerne un polypeptide chimère de formule: pTox-pTarg, dans laquelle pTox représente un peptide apoptotique viral, tel que le peptide Vpr du VIH-1 ou un fragment du peptide Vpr du VIH-1 contenant le motif acide aminé H(F/S)RIG qui interagit avec la protéine de translocation d'adénonucléotide (ANT) de la membrane interne mitochondriale dans une cellule. pTarg représente un anticorps ou un fragment d'anticorps qui se lie à la membrane externe de la cellule. La liaison du polypeptide chimère à la cellule est suivie de l'apoptose de la cellule. L'invention concerne aussi un vecteur codant pour un polypeptide chimère et une cellule hôte recombinante contenant ce vecteur. Le polypeptide chimère est utile pour diriger pTox vers des cellules, telles que des cellules cancéreuses.

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