Chimeric neurotrophic factors

Details Chimeric neurotrophic factors Chimeric neurotrophic factors

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) C07K 14/48 (2006.01) C07K 14/82 (2006.01) C07K 19/00 (2006.01) C12N 15/16 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2088990

2088990 9202620 PCTABS00010 The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occuring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It is based, in part, on the discovery that chimeric molecules comprising portions of both NGF and BDNF are likely to possess neurotrophic activity, and in some cases exhibit a spectrum of activity larger than that of either parent molecule. It is further based on the discovery that chimeric molecules comprising neurotrophic factor sequences as well as additional peptide sequences may retain neurotrophic activity, and in some cases may exhibit a more potent activity than the parent factor. The chimeric neurotrophic factor molecules of the invention provide a number of advantages relative to naturally occurring neurotrophic factors. Chimeric neurotrophic factors may be used to provide, for example, the activity of two neurotrophic factors in a single molecule, or may serve as superagonists of an endogenous neurotrophic factor, thereby enabling an increased biological response at lower doses.

Affiliated with

Also associated with

Rating

Chimeric neurotrophic factors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric neurotrophic factors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric neurotrophic factors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1746129