C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/01 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01) A61K 39/155 (2006.01) A61K 39/385 (2006.01) C07K 19/00 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2678966
The present invention discloses and claims chimeric virus like particles (VLPs) that express and/or contains Newcastle disease matrix protein. The invention includes vector constructs comprising said proteins, cells comprising said constructs, formulations and vaccines comprising chimeric VLPs of the inventions. The invention also includes methods of making and administrating chimeric VLPs to vertebrates, including methods of inducing immunity to infections.
La présente invention décrit et revendique des pseudo-particules virales chimériques (VLP) qui expriment et/ou contiennent la protéine matricielle de la maladie de Newcastle. L'invention comprend des produits de recombinaison de vecteurs comprenant lesdites protéines, des cellules comprenant lesdits produits de recombinaison, des formulations et des vaccins comprenant les VLP chimériques de l'invention. L'invention comprend également des procédés de préparation et d'administration des VLP chimériques à des vertébrés, y compris des méthodes d'induction de l'immunité pour lutter contre les infections.
Mahmood Kutub
Pushko Peter
Smith Gale
Deeth Williams Wall Llp
Novavax Inc.
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