Chimeric oligomers having an rna-cleavage activity

Details Chimeric oligomers having an rna-cleavage activity Chimeric oligomers having an rna-cleavage activity

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A61K 31/70 (2006.01) C12N 9/22 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2237528

New chimeric oligomers having an RNA-cleavage activity, as well as their use for cleaving RNA-substrates in vitro and in vivo have been disclosed. The new chimeric oligomers contain an active centre, the building blocks of which are selected from nucleotides or/and nucleotide analogues, as well as flanking regions contributing to the formation of a specific hybridization of the oligomer with an RNA-substrate and containing at least one building block which is different from deoxyribonucleotides and ribonucleotides.

On décrit des nouveaux oligomères chimériques possédant une activité de clivage de l'ARN, de même que l'utilisation de ces oligomères pour cliver, in vitro et in vivo, des substrats d'ARN. Ces nouveaux oligomères contiennent un centre actif, dont les éléments structuraux sont choisis parmi des nucléotides et/ou des analogues de nucléotides, ainsi que des régions adjacentes, lesquelles contribuent à la formation d'une hybridation spécifique de l'oligomère avec un substrat d'ARN et contiennent au moins un élément structural différent des désoxyribonucléotides et des ribonucléotides.

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