C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C12N 15/62 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2288351
Chimeric polypeptides comprising fusions of an osteoprotegerin dimerization domain to a heterologous sequence are provided. Also provided are nucleic acids encoding the polypeptides, expression vectors and host cells for their production and pharmaceutical compositions comprising the polypeptides.
La présente invention concerne des polypeptides chimères comprenant des fusions d'un domaine de dimérisation d'une ostéoprotégérine et d'une séquence hétérologue. L'invention se rapporte également à des acides nucléiques codant les polypeptides, à des vecteurs d'expression et à des cellules hôtes destinées à leur production, et à des compositions pharmaceutiques contenant lesdits polypeptides.
Boyle William J.
Wooden Scott
Amgen Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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