Chimeric parvovirus vectors and methods of making and...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 7/01 (2006.01) A61K 35/76 (2006.01) A61K 48/00 (2006.01) C12N 5/10 (2006.01) C12N 7/02 (2006.01) C12N 15/00 (2006.01) C12N 15/35 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/864 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2348382

The present invention provides genetically-engineered parvovirus capsids and viruses designed to introduce a heterologous gene into a target cell. The parvoviruses of the invention provide a repertoire of vectors with altered antigenic properties, packaging capabilities, and/or cellular tropisms as compared with current AAV vectors.

La présente invention concerne des capsides et des virus à parvovirus génétiquement modifiés, destinés à introduire un gène hétérologue dans une cellule cible. Les parvovirus de cette invention fournissent un répertoire immunologique des vecteurs présentant une altération de leurs propriétés antigéniques, de leurs capacités d'encapsidation, et/ou de leurs tropismes cellulaires, par rapport aux vecteurs AAV actuels.

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