C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/64 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61P 3/06 (2006.01) C07K 14/05 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/37 (2006.01) G01N 33/567 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2652247
A chimera protein comprising in the following order : a signal peptide, a proprotein convertase subtilisin/kexin type 9 preproprotein (PCSK9) sequence consisting of amino acid residues at positions 35 to 696 of SEQ ID NO: 38, a transmembrane domain and a cytosolic domain, wherein said cytosolic (CT) domain comprises a sequence able to recycle the protein from the cellular membrane to endosomes.
L'invention concerne une protéine chimère comprenant dans l'ordre suivant : un peptide signal, une séquence de préproprotéine de proprotéine convertase subtilisine/kexine type 9 (PCSK9) consistant en résidus d'acides aminés dans les positions 35 à 696 de SEQ ID NO: 38, un domaine transmembranaire et un domaine cytosolique, le domaine cytosolique (CT) comprenant une séquence capable de recycler la protéine de la membrane cellulaire aux endosomes.
Bernier Lise
Davignon Jean
Dubuc Genevieve
Seidah Nabil
Tremblay Michel
Adaerata Limited Partnership
Goudreau Gage Dubuc
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