C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.04
C07K 7/04 (2006.01) A61K 47/48 (2006.01) C07K 1/107 (2006.01) C07K 7/16 (2006.01) C07K 14/62 (2006.01) C07K 14/655 (2006.01) C07K 14/675 (2006.01) C07K 14/695 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1311086
63-293/UC9.10 CHIMERIC PEPTIDES FOR NEUROPEPTIDE DELIVERY THROUGH THE BLOOD-BRAIN BARRIER ABSTRACT OF THE INVENTION Chimeric peptides adapted for delivering neuro- pharmaceutical agents, such as neuropeptides into the brain by receptor-mediated transcytosis through the blood-brain barrier. The chimeric peptides include a peptide which by itself is capable of crossing the blood- brain barrier by transcytosis at a relatively high rate. The transportable peptide is conjugated to a hydrophilic neuropeptide which by itself is transportable only at a very low rate into the brain across the blood-brain barrier. The resulting chimeric peptide is transported into the brain at a much higher rate than the neuro- peptide alone to thereby provide an effective means for introducing hydrophilic neuropeptides into the brain through the blood-brain barrier.
543217
Smart & Biggar
The Regents Of The University Of California
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