Chimeric polypeptide comprising the fragment b of shiga...

Details Chimeric polypeptide comprising the fragment b of shiga... Chimeric polypeptide comprising the fragment b of shiga...

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 14/245 (2006.01) C07K 14/25 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2296711

The invention concerns a polypeptide sequence comprising the fragment B of Shiga toxin or a functional equivalent thereof bound at the carboxy-terminal end with one or several polypeptides corresponding to the formula B - X in which B represents the fragment B of the Shiga toxin and X represents one or several polypeptides of therapeutic interest, and its use as active principle in a therapeutic composition.

L'invention se rapporte à une séquence polypeptidique comprenant le fragment B de la toxine de Shiga ou un équivalent fonctionnel de celui-ci liée à l'extrémité carboxy-terminale à un ou plusieurs polypeptides répondant à la formule B - X dans laquelle B représente le fragment B de la toxine de Shiga et X représente un ou plusieurs polypeptides d'intérêt thérapeutique, et son utilisation comme principe actif d'une composition thérapeutique.

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