Chimeric promoters for controlling expression in muscle cells

Details Chimeric promoters for controlling expression in muscle cells Chimeric promoters for controlling expression in muscle cells

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 35/12 (2006.01) A61K 35/76 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 7/00 (2006.01) C12N 15/09 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2406687

The present invention concerns chimeric constructs comprising a skeletal alpha- actin gene promoter operably linked with at least a skeletal muscle-specific enhancer of a human gene. It also provides an expression cassette comprising such a chimeric construct to control expression of a gene of interest. The invention also relates to a vector, a viral particle, an eukaryotic host cell, a pharmaceutical composition comprising said expression cassette and their use for specific expression in skeletal muscle cells as well as for therapeutic or prophylactic purposes. Finally, the present invention also provides the therapeutic use of an expression cassette, a vector and a viral particle comprising a gene of interest placed under the control of a skeletal alpha-actin gene promoter and a muscle-specific enhancer, especially for treating peripheral ischemia.

Affiliated with

Also associated with

Rating

Chimeric promoters for controlling expression in muscle cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Chimeric promoters for controlling expression in muscle cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric promoters for controlling expression in muscle cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1520632