C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2511213
The invention relates to a chimeric protein which is derived from a high-threshold calcium channel and which is characterised in that it consists of at least one .beta. subunit or a fragment of same comprising at least the BID domain, which is fused at the NH¿2? or COOH end thereof with the I-II loop of an .alpha.¿1? subunit or a fragment of same comprising at least the AID domain. The invention also relates to the applications of said protein in the study of cell signalling pathways that are dependent on G-protein-coupled receptors (GPCR) and the identification of compounds that modulate the activity of G proteins. ?¿
Protéine chimérique dérivée d'un canal calcique haut seuil, caractérisée en ce quelle comprend au moins une sous-unité .beta. ou un fragment de celle-ci incluant au moins le domaine BID, fusionné(e) ô son extrémité NH2#191 ou COOH avec la boucle I-II d'une sous-unité .alpha.1 ou un fragment de celle-ci incluant au moins le domaine AID, et ses applications pour l'étude des voies de signalisation cellulaire dépendantes des récepteurs couplés aux protéines G (RCPG) et l'identification de composés modulant l'activité des protéines G.
de Waard Michel
Dupuis Alain
Grunwald Didier
Sandoz Guillaume
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