Chimeric proteins

Details Chimeric proteins Chimeric proteins

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/09 (2006.01) A61K 39/385 (2006.01) C07K 14/28 (2006.01) C07K 19/00 (2006.01) C12N 9/10 (2006.01) C12N 15/31 (2006.01) C12N 15/54 (2006.01)

Patent

CA 2069106

2069106 9107979 PCTABS00005 A chimeric peptide is provided which includes at least a portion of the B subunit of cholera toxin and an epitope region of a desired antigen fused to the N-terminal end of the B subunit of cholera toxin. The epitope region includes an antigenic determinant of the desired peptide. According to certain preferred embodiments, such chimeric peptides are used as a vaccine to elicit an immune response in a subject to a desired antigen. Recombinant-DNA mediated methods for the production of a chimeric peptide, DNA sequences, vectors and host organisms used in such methods are also provided.

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