C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) C07K 16/38 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 15/15 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2196290
Chimeric proteins possessing Kunitz-type domain 1 of TFPI-2 and Kunitz-type domain 2 of TFPI are disclosed, as are muteins of TFPI and TFPI-2. Nucleic acid sequences, expression vectors and transformed host cells encoding and capable of producing the disclosed chimeric proteins and muteins are also disclosed. Finally, methods for prevention and treatment of septic shock using the chimeric proteins and muteins are disclosed.
Protéines chimériques qui possèdent le domaine 1 de type Kunitz de TFPI-2 et le domaine 2 de type Kunitz de TFPI, ainsi que mutéines de TFPI et TFPI-2. Des séquences d'acides nucléiques, des vecteurs d'expression et des cellules hôtes transformées codant les protéines chimériques et les mutéines selon la présente invention et capables de les produire sont également décrits. Enfin, l'invention concerne aussi des procédés de prévention et de traitement du choc septique à l'aide desdites protéines chimériques et mutéines.
Creasey Abla A.
Innis Michael A.
Chiron Corporation
Novartis Vaccines And Diagnostics Inc.
Sim & Mcburney
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