Chimeric proteins and uses thereof

Details Chimeric proteins and uses thereof Chimeric proteins and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/00 (2006.01) C07K 14/705 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2571781

The present invention provides a chimeric protein capable of killing or modifying a cell expressing abnormally high levels of a ligand of a receptor of the TNF/NGF family, comprising the amino acid sequence of at least one polypeptide consisting of an extracellular portion of said receptor connected to an effector molecule. In addition the invention provides pharmaceutical compositions comprising said chimeric protein and use thereof.

L'invention concerne une protéine chimère pouvant éliminer ou modifier une cellule exprimant des niveaux anormalement élevés d'un ligand d'un récepteur de la famille TNF/NGF, qui comprend la séquence d'acides aminés d'au moins un polypeptide constitué d'une partie extracellulaire dudit récepteur relié à une molécule effectrice. L'invention concerne en outre des compositions pharmaceutiques comprenant ladite protéine chimère et l'utilisation de celles-ci.

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