Chimeric proteins comprising borrelia polypeptides: uses...

Details Chimeric proteins comprising borrelia polypeptides: uses... Chimeric proteins comprising borrelia polypeptides: uses...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/02 (2006.01) C07K 14/20 (2006.01) C07K 19/00 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2175567

Novel chimeric nucleic acids, encoding chimeric Borrelia proteins consisting of at least two antigenic polypeptides from corresponding and/or non-corresponding proteins from the same and/or different species of Borrelia, are disclosed. Chimeric proteins encoded by the nucleic acid sequences are also disclosed. The chimeric proteins are useful as vaccine immunogens against Lyme borreliosis, as well as for immunodiagnostic reagents.

L'invention concerne de nouveaux acides nucléiques chimères codant des protéines chimères de Borrelia se composant d'au moins deux polypeptides antigéniques des protéines correspondantes et/ou non correspondantes de la même espèce et/ou d'une espèce différente de Borrelia. Des protéines chimères codées par les séquences d'acides nucléiques sont également décrites et sont utiles en tant que vaccins immunogènes contre les borrélioses de Lyme comme les réactifs immunodiagnostiques.

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