C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 38/40 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/79 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2221711
Chimeric proteins useful in transporting a selected substance present in extracellular fluids, such as blood or lymph, into cells; quantitative assays for the selected substance using chimeric proteins; DNA encoding the chimeric proteins; plasmids which contain DNA encoding the chimeric proteins; mammalian cells, modified to contain DNA encoding the chimeric proteins, which express and, optionally, secrete the chimeric proteins; a method of producing the chimeric proteins; a method of isolating the chimeric proteins; a method of using the chimeric proteins to assay the selected substance; and a method of reducing extracellular levels of the selected substance through administration of the chimeric protein, which results in transport of the selected substance into cells.
Protéines chimères servant à l'acheminement dans les cellules d'une substance choisie présente dans les fluides extracellulaires, tels que le sang ou la lymphe; dosages de la substance choisie au moyen de protéines chimères; ADN codant les protéines chimères; plasmides contenant l'ADN codant les protéines chimères; cellules de mammifères modifiées pour contenir l'ADN codant les protéines chimères, qui exprime, et éventuellement sécrète les protéines chimères; procédé de production des protéines chimères; procédé d'isolement des protéines chimères; utilisation des protéines chimères pour doser la substance choisie; et procédé de réduction des niveaux extracellulaires de la substance choisie par l'administration de la protéine chimère, aboutissant à l'acheminement de la substance choisie dans les cellules.
Concino Michael F.
Heartlein Michael W.
Lemontt Jeffrey F.
Shire Human Genetic Therapies Inc.
Smart & Biggar
Transkaryotic Therapies Inc.
LandOfFree
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