Chimeric proteins mediating targeted apoptosis

Details Chimeric proteins mediating targeted apoptosis Chimeric proteins mediating targeted apoptosis

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2377489

Chimeric cell-surface proteins are described which may be used in the selective induction of apoptosis in particular target cell types such as cancer cells in vivo or in vitro. Nucleic acid sequences encoding such proteins and methods of use relating to cancer and other therapies are provided.

L'invention concerne des protéines chimères de surface cellulaire qui peuvent être utilisées pour induire, de manière sélective, l'apoptose dans des types de cellules cibles particulières, comme des cellules cancéreuses in vivo ou in vitro. L'invention traite aussi des séquences d'acides nucléiques codant ces protéines et de procédés d'utilisation pour soigner le cancer et pouvant être utilisés pour d'autres thérapies.

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