C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61P 3/10 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 31/00 (2006.01) A61P 31/02 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) C07K 7/23 (2006.01) C07K 14/47 (2006.01) C07K 14/485 (2006.01) C07K 14/52 (2006.01) C07K 14/55 (2006.01) C07K 14/65 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2321996
The present invention relates to chimeric proteins with cell-targeting specificity and apoptosis-inducing activities. In particular, the invention is illustrated by a recombinant chimeric protein between human interleukin-2 (IL2) and Bax. The chimeric protein specifically targets IL2 receptor (IL2R)- expressing cells and induces cell-specific apoptosis.
L'invention concerne des protéines chimères actives du point de vue d'un ciblage et d'une induction d'apoptose spécifiques de cellules. En particulier, l'invention concerne une protéine chimère recombinée entre l'interleukine-2 humaine (IL2) et Bax. Cette protéine chimère cible de manière spécifique des cellules exprimant le récepteur d'IL2 (IL2R) et provoque une apoptose spécifique de ces cellules.
Aqeilan Rami Ishaq
Azar Yehudith
Belostotsky Ruth
Ben-Yehudah Ahmi
Lorberboum-Galski Haya
Osler Hoskin & Harcourt Llp
Yissum Research Development Company Of The Hebrew University In
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