Chimeric proteins with phosphatidylserine binding domains

Details Chimeric proteins with phosphatidylserine binding domains Chimeric proteins with phosphatidylserine binding domains

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01)

Patent

CA 2608070

Chimeric proteins comprising soluble Tissue Factor (sTF) and another subunit (e.g., annexin V) are described. The proteins promote blood clotting and/or inhibit cancer by targeting sTF to specific receptors such as phosphatidyl serine (PS) on activated cells. These chimeric proteins are useful in treating patients with excessive bleeding due to inborn problems, drug therapy, trauma or surgery and/or as an anti-cancer therapy, for example by causing blood vessels feeding cancers to become clotted, thereby preventing adequate flow of blood to a tumor, which in turn will lead to tumor inhibition and death or may be used in a therapy to cause clotting within blood vessels that pose a threat in the subject in non-cancerous conditions.

L'invention porte sur des protéines chimériques contenant un facteur de tissu soluble (sTF) et une autre sous-unité (par exemple annexine V). ces protéines favorisent la coagulation sanguine et/ou inhibent le cancer par ciblage de sTF avec des récepteurs spécifiques tels que phosphatidylsérine (PS) sur des cellules activées. Ces protéines chimériques sont utiles dans le traitement de patients souffrant de saignements excessifs en raison de problèmes congénitaux, de soins par médicaments, de traumatismes ou d'une opérations chirurgicale, et/ou dans une thérapie anticancéreuse, en provoquant par exemple la coagulation de vaisseaux sanguins alimentant les cancers, empêchant ainsi le flux approprié de sang vers une tumeur, ce qui provoquera ainsi l'inhibition ou la mort de la tumeur. Ces protéines peuvent aussi être utilisées pour provoquer la coagulation de vaisseaux sanguins qui représentent une menace à un sujet dans des conditions non cancéreuses.

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