Chimeric receptor genes and cells transformed therewith

Details Chimeric receptor genes and cells transformed therewith Chimeric receptor genes and cells transformed therewith

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 35/14 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2132349

The disclosed invention relates to chimeric genes which contain a first segment encoding a single chain Fv domain of a specific antibody and a second segment encoding at least the transmembrane and cytoplasmic domains of an immune cell-trig-gering molecule such as subunits of either a T cell receptor, a T cell receptor-CD3 complex, a Fc receptor or an IL-2 receptor. Al-so disclosed is a method of treatment of a tumor using lymphocyte cells transformed with expression vectors containing the chi-meric genes.

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