C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A01K 67/027 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07K 14/15 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C12N 5/10 (2006.01) C12N 7/04 (2006.01) C12N 15/62 (2006.01) C12N 15/85 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2137547
Chimeric receptor polypeptides are disclosed which contain chimeric viral receptors of a first species which bind non-first species specific viruses and/or their envelope protein env binding domains, nucleic acid encoding therefore, cells or tissues ex- pressing the chimeric receptor polypeptide, as well as methods of preparing and using thereof. Also disclosed are methods for rendering eukaryotic cells or tissues selectively susceptible to binding and/or infection by recombinant viral vectors or delivery vectors that bind a chimeric receptor of a chimeric receptor polypeptide expressed in target cells or tissues. Also disclosed are gene therapy methods which may be used on selected cells or tissues of a mammal, bird, insect or yeast through the use of tran- sient or constitutive expression or vector association of a chimeric receptor polypeptide having a chimeric receptor binding site. The resulting chimeric receptor cells or tissues are thus rendered susceptible to infection or binding by viral vectors or env binding domains thereof which specifically bind the chimeric receptor. The chimeric receptor cells are then susceptible to infection and/ or binding by therapeutic and/or diagnostic agents which comprise an env binding domain of a non-first species specific virus capable of binding a chimeric receptor polypeptide of the present invention.
Meruelo Daniel
Yoshimoto Takayuki
New York University
Osler Hoskin & Harcourt Llp
LandOfFree
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