C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/64 (2006.01) A61K 31/13 (2006.01) A61K 38/22 (2006.01) A61K 38/28 (2006.01) A61K 38/30 (2006.01) A61P 9/00 (2006.01) A61P 25/00 (2006.01) C07K 14/575 (2006.01) C07K 14/62 (2006.01) C07K 14/65 (2006.01) C07K 19/00 (2006.01) C12N 15/16 (2006.01) C12N 15/17 (2006.01) C12N 15/18 (2006.01)
Patent
CA 2704246
Modified relaxin polypeptides are disclosed wherein the B chain comprises the core sequence CGRxxxRxxI/VxxCG (SEQ ID NO: 1), specifically KLCGRELVRAQIAIC. Chimeric polypeptides comprising a B chain with the core sequence CGRxxxRxxFVxxCG (SEQ ID NO: 1) and an A chain from a heterologous relaxin family peptide are also disclosed. Specifically, chimeric polypeptides comprising a B chain from relaxin-2, and an A chain from relaxin- 1, relaxin-3, insulin, IGF-I, IGF-II, INSL3, INSL4, INSL5 or INSL6, are disclosed.
L'invention porte sur des polypeptides modifiés de la relaxine, dans lesquels la chaîne B comprend la séquence cur CGRxxxRxxI/VxxCG (SEQ ID NO: 1), spécifiquement KLCGRELVRAQIAIC. L'invention porte également sur des polypeptides chimériques comprenant une chaîne B comportant la séquence cur CGRxxxRxxFVxxCG (SEQ ID NO: 1) et une chaîne A provenant d'un peptide hétérologue de la famille de la relaxine. De façon spécifique, l'invention porte sur des polypeptides chimériques comprenant une chaîne B provenant de la relaxine-2 et une chaîne A provenant de la relaxine-1, de la relaxine-3, de l'insuline, d'IGF-I, d'IGF-II, d'INSL3, d'INSL4, d'INSL5 ou d'INSL6.
Bathgate Ross Alexander David
Hossain Mohammed Akhter
Samuel Chrishan Surendran
Tregear Geoffrey W.
Wade John Desmond
Gowling Lafleur Henderson Llp
Howard Florey Institute Of Experimental Physiology And Medicine
LandOfFree
Chimeric relaxin polypeptides comprising an a and b chain... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Chimeric relaxin polypeptides comprising an a and b chain..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Chimeric relaxin polypeptides comprising an a and b chain... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1785290