Chimeric rnas and their use for cancer diagonostics and therapy

Details Chimeric rnas and their use for cancer diagonostics and therapy Chimeric rnas and their use for cancer diagonostics and therapy

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2526639

A novel family of human mitochondrial RNAs, referrred to as chimeric RNAs, which are differentially expressed in normal, pre-cancer and cancer cells, are described. Oligonucleotides targeted to the chimeric RNAs are provided. The described oligonucleotides or their analogs can be used for cancer diagnostics and cancer therapy as well as for research. In one embodiment of this invention, these oligonucleotides hybridize with the sense or with the antisense mitochondrial chimeric RNAs, and the result of the hybridization is useful to differentiate between normal proliferating cells, pre-cancer cells and cancer cells. In another embodiment of the invention, the compositions comprise oligonucleotides that hybridize with the human chimeric RNAs resulting in cancer cell and pre-cancer cell death, while there is no effect in normal cells, constituting therrefore, a novel approach for cancer therapy.

L'invention concerne une nouvelle famille d'ARN mitochondriaux humains, désignés sous le nom d'ARN chimères, qui sont exprimés de manière différentielle dans des cellules précancéreuses et cancéreuses normales. L'invention concerne également des oligonucléotides ciblés sur l'ARN chimère. Les oligonucléotides décrits ou leurs analogues peuvent être utilisés dans le diagnostic et le traitement des cancers ainsi que dans la recherche. Dans un mode de réalisation, ces oligonucléotides s'hybrident avec les ARN chimères mitochondriaux sens ou antisens et le résultat de l'hybridation permet de différencier les cellules en mitose normales, les cellules précancéreuses et les cellules cancéreuses. Dans un autre mode de réalisation, ces compositions comprennent des oligonucléotides qui s'hybrident avec les ARN chimères humains provoquant la mort des cellules cancéreuses et précancéreuses, sans pour autant entraîner d'effet chez les cellules normales, constituant ainsi une nouvelle approche du traitement du cancer.

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