Chimeric small molecules for the recruitment of antibodies...

Details Chimeric small molecules for the recruitment of antibodies... Chimeric small molecules for the recruitment of antibodies...

G - Physics

01

N

G01N 33/574 (2006.01)

Patent

CA 2723816

The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus(CBT) through a linker and optionally, a connector molecule.

La présente invention porte sur des composés chimiques chimériques qui sont utilisés pour recruter des anticorps dirigés contre des cellules cancéreuses, en particulier, des cellules cancéreuses de la prostate ou des cellules cancéreuses de la prostate métastasées. Les composés selon la présente invention comprennent une fraction à extrémité de liaison à un anticorps (ABT) liée de façon covalente à une extrémité de liaison à une cellule (CBT) par un liant et facultativement, une molécule de jonction.

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