Chimeric soluble hyper il-11 and use thereof

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/54 (2006.01) A61K 38/20 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2564770

The present invention concerns a new designer cytokine termed H11, which is constructed by fusion of two soluble components, soluble interleukin 11 receptor (sIL-11 R) and interleukin 11 (IL-11) using their natural sequence and its use for the production of a medicament for treating or preventing a disease selected from the group consisting of a proliferative disease, a cytopathy, radiation damage, an IL-11 dependent inflammatory disorder, IL-11 dependent degenerative disorder and IL-11 dependent or mediated soft tissue disorder.

L'invention concerne une nouvelle cytokine conçue appelée H11, construite par fusion de deux composants solubles, du récepteur de l'interleukine 11 soluble (sIL-11R) et l'interleukine 11 (IL-11) au moyen de leur séquence naturelle et leur utilisation pour la production d'un médicament de traitement ou de prévention d'une maladie du groupe comprenant les maladies à prolifération, la cytopathie, les dommages causés par les rayonnements, un trouble inflammatoire dépendant d'IL-11, un trouble de dégénérescence dépendant d'Il-11 et une anomalie des tissus mous dépendant d'Il-11 ou induite par IL-11.

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