C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/54 (2006.01) A61K 38/20 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2564770
The present invention concerns a new designer cytokine termed H11, which is constructed by fusion of two soluble components, soluble interleukin 11 receptor (sIL-11 R) and interleukin 11 (IL-11) using their natural sequence and its use for the production of a medicament for treating or preventing a disease selected from the group consisting of a proliferative disease, a cytopathy, radiation damage, an IL-11 dependent inflammatory disorder, IL-11 dependent degenerative disorder and IL-11 dependent or mediated soft tissue disorder.
L'invention concerne une nouvelle cytokine conçue appelée H11, construite par fusion de deux composants solubles, du récepteur de l'interleukine 11 soluble (sIL-11R) et l'interleukine 11 (IL-11) au moyen de leur séquence naturelle et leur utilisation pour la production d'un médicament de traitement ou de prévention d'une maladie du groupe comprenant les maladies à prolifération, la cytopathie, les dommages causés par les rayonnements, un trouble inflammatoire dépendant d'IL-11, un trouble de dégénérescence dépendant d'Il-11 et une anomalie des tissus mous dépendant d'Il-11 ou induite par IL-11.
Dams-Kozlowska Hanna
Mackiewicz Andrzej
Rose-John Stefan
Agirx Limited
G. Ronald Bell & Associates
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