C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) C07K 14/725 (2006.01)
Patent
CA 2651174
The invention provides a chimeric T cell receptor (TCR) comprising a variable region of a human TCR and a constant region comprising at least an extracellular domain of a constant region of a non-human TCR, as well as functional variants thereof. The invention also provides polypeptides and proteins related to the inventive TCRs, as well as nucleic acids encoding the TCRs, polypeptides, or proteins, recombinant expression vectors, and host cells. Further provided are pharmaceutical compositions related to the inventive TCRs and methods of preventing or treating a disease, e.g., an infectious disease, cancer, in a host, methods of detecting a diseased cell in a host, and methods of improving the biological activity of a TCR.
L'invention concerne un récepteur de lymphocyte T (TCR) chimérique comprenant une région variable d'un TCR humain et une région constante renfermant au moins un domaine extracellulaire d'une région constante d'un TCR non humain, ainsi que des variants fonctionnels correspondants. L'invention concerne également des polypeptides et des protéines associés aux TCR susmentionnés ainsi que des acides nucléiques codant pour ces TCR, ces polypeptides ou ces protéines, des vecteurs d'expression recombinés et des cellules hôtes. L'invention porte en outre sur des compositions pharmaceutiques associées aux TCR susmentionnés ainsi que sur des méthodes de prévention ou de traitement d'une maladie, telle qu'une maladie infectieuse ou un cancer, chez un hôte, des méthodes de détection d'une cellule malade chez un hôte et des méthodes destinées à améliorer l'activité biologique d'un TCR.
Cohen Cyrille J.
Morgan Richard A.
Rosenberg Steven A.
Department Of Health And Human Services Government Of The United States Of America Represented By The Se
Ridout & Maybee Llp
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