Chimeric trnalys-ribozyme molecules

Details Chimeric trnalys-ribozyme molecules Chimeric trnalys-ribozyme molecules

C - Chemistry, Metallurgy

07

H

C07H 21/02 (2006.01) A61K 31/70 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2114312

2114312 9324133 PCTABS00028 The invention provides novel chimeric tRNALYS-ribozyme molecules that compete effectively with tRNALYS for HIV-1 reverse transcriptase binding sites. The chimeric human tRNALYS-ribozymes inhibit reverse HIV transcription by delivering inhibitors such as ribozymes of HIV-1 reverse transcriptase directly to the virion particle and render it non-functional. The chimeric molecules of the invention thus serve as highly specific non-toxic therapeutic agents. These chimeric molecules also reveal a novel, site specific RNA cleaving activity of HIV-1.

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