Chimeric vaccine antigens against classical swine fever virus

Details Chimeric vaccine antigens against classical swine fever virus Chimeric vaccine antigens against classical swine fever virus

A - Human Necessities

61

K

A61K 39/12 (2006.01) C07K 14/18 (2006.01) C07K 14/705 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2638830

The present invention describes chimeric vaccine antigens against the virus that causes classical swine fever (CSFV). Said vaccine antigens are based on viral subunits that are coupled to protein molecules that stimulate not only the cellular but also the humoral immune system. The chimeric antigens may by produced in expression systems that guarantee correct three-dimensional folding of the chimeric molecules that constitute the basis of the present invention. The vaccine compositions that contain said chimeric antigens induce a potent, early immune response in vaccinated pigs, conferring total protection against CSFV. In addition, the resulting vaccine compositions prevent viral transmission from sow to progeny. The chimeric antigens, and also the resulting vaccine compositions, are applicable to the field of animal health as vaccines for preventive use in swine.

L'invention concerne des antigènes vaccinaux chimères utilisés contre le virus qui entraîne la maladie de la peste procine classique (VPPC). Ces antigènes vaccinaux sont basés sur des sous-unités virales couplées à des molécules protéiques stimulatrices du système immunitaire, tant sur le plan cellulaire qu'humoral. Les antigènes chimères peuvent être produits dans des systèmes d'expression qui garantissent un pliage tridimensionnel correct des molécules chimères qui constituent la base de cette invention. Les compositions de vaccin contenant ces antigènes chimères induisent une réponse immunitaire puissante et rapide chez les porcs vaccinés, leur conférent une protection totale contre le VPPC. En outre, ces compositions de vaccin préviennent la transmission virale par la mère à sa descendance. Les antigènes chimères, ainsi que les compositions de vaccin obtenues peuvent être appliquées au domaine de la santé animale, en tant que vaccins préventifs chez les porcins.

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