Chimeric vaccine for haemophilus influenzae-induced disease

Details Chimeric vaccine for haemophilus influenzae-induced disease Chimeric vaccine for haemophilus influenzae-induced disease

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/102 (2006.01) A61K 39/116 (2006.01) A61P 31/04 (2006.01) C07K 14/195 (2006.01) C07K 14/285 (2006.01) C07K 16/12 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2613970

The invention described herein relates to a chimeric protein comprising the NTHi twitching pilus major subunit protein (PilA) presenting a portion of the NTHi OMP P5 protein. The invention provides for vaccine compositions comprising the recombinant chimeric protein and methods of eliciting an immune response using the recombinant chimeric proteins of the invention.

L'invention se rapporte une protéine chimère qui comprend la protéine de la sous-unité principale du pilus à mobilité de type "twitching" de NTHi (PilA), présentant une partie de la protéine OMP P5 de NTHi. L'invention concerne des compositions vaccinales contenant cette protéine chimère recombinée, ainsi que des méthodes permettant de déclencher une réponse immunitaire par l'utilisation des protéines chimères décrites.

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