Chimeric vectors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/864 (2006.01) A61K 48/00 (2006.01) C12N 7/01 (2006.01) C12N 15/35 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01)

Patent

CA 2591544

The present invention is based, in part, on the discovery that parvovirus (including AAV) capsids can be engineered to incorporate small, selective regions from other parvoviruses that confer desirable properties. The inventors have discovered that in some cases as little as a single amino acid insertion or substitution from a first parvovirus (e.g., an AAV) into the capsid structure of another parvovirus (e.g., an AAV) to create a chimeric parvovirus is sufficient to confer one or more of the desirable properties of the first parvovirus to the resulting chimeric parvovirus and/or to confer a property that is not exhibited by the first parvovirus or is present to a lesser extent.

L'invention concerne, en partie, la découverte selon laquelle des capsides de parvovirus (notamment AAV) peuvent être travaillés de manière à renfermer des petites régions sélectives provenant d'autres parvovirus conférant des propriétés souhaitées. Dans quelques cas, une seule introduction ou substitution d'acide aminé à partir d'un premier parvovirus (par exemple, un AAV) dans la structure des capsides d'un autre parvovirus (par exemple, un AAV) aux fins de création d'un parvovirus chimérique suffit pour conférer une ou plusieurs propriétés souhaitées du premier parvovirus au parvovirus chimérique obtenu et/ou pour conférer une propriété non présentée par le premier parvovirus ou présente de manière moins importante.

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