Chimeric virus-like particles

Details Chimeric virus-like particles Chimeric virus-like particles

C - Chemistry, Metallurgy

12

N

C12N 7/01 (2006.01) A61K 39/12 (2006.01) A61P 37/04 (2006.01) C12N 7/00 (2006.01) C12N 7/04 (2006.01) C12N 15/85 (2006.01) C07K 14/11 (2006.01) C07K 14/15 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2657955

Chimeric virus-like particles including gag polypeptides are described. Virus-like particles are generated with a gag polypeptide and lipid raft-associated polypeptide linked to an antigen that is not naturally associated with a lipid raft. Preferred methods of generation include expression in insect cells.

L'invention concerne des particules de type virus chimérique comprenant des polypeptides gag. Des particules de type virus sont générées avec un polypeptide gag et un polypeptide associé à un radeau lipidique lié à un antigène qui n'est pas naturellement associé à un radeau lipidique. Des procédés préférés de génération incluent l'expression dans des cellules d'insecte.

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