Chinese hamster ovary cell lines

Details Chinese hamster ovary cell lines Chinese hamster ovary cell lines

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/071 (2010.01) C07K 14/505 (2006.01) C12N 15/52 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2737748

We provide a Chinese Hamster Ovary (CHO) cell which is capable of higher protein sialylation compared to a wild type Chinese Hamster Ovary cell, such as in the presence of functional GnT 1, in which the CHO cell is obtainable by selection with Ricinus communis agglutinin I(RCA-I).

La présente invention concerne une cellule ovarienne de hamster de Chine, qui est apte à induire une sialylation des protéines, supérieure à celle de la cellule ovarienne de hamster de Chine de type sauvage, tel qu'en présence de GnT 1 fonctionnel. Cette cellule ovarienne de hamster de Chine peut s'obtenir par sélection par l'agglutinine I de Ricinus communis (RCA-I).

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