Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key...

Details Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key... Chiral 3-carbamoylmethyl-5-methyl hexanoic acids, key...

C - Chemistry, Metallurgy

07

C

C07C 233/05 (2006.01) C07C 227/32 (2006.01) C07C 229/08 (2006.01) C07C 231/18 (2006.01)

Patent

CA 2619472

The invention encompasses the synthesis of (S)-(+)-3-(aminomethyl)-5- methylhexanoic acid, (S)-Pregabalin, via the intermediate, (3R)-5-methyl-3-(2- oxo-2{[(lR)- l-phenylethyl]amino} ethyl)hexanoic acid.

La présente invention concerne la synthèse de l'acide (S)-(+)-3-(aminométhyl)-5-méthylhexanoïque [(S)-Prégabaline] via l'intermédiaire acide (3R)-5-méthyl-3-(2-oxo-2{[(1R)- 1-phényléthyl]amino}éthyl)hexanoïque.

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