Chiral fused [1,2]imidazo[4,5-c] ring compounds

C - Chemistry – Metallurgy – 07 – D

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C07D 491/02 (2006.01)

Patent

CA 2592904

Fused [1,2]imidazo[4,5-c] ring compounds (e.g., imidazo[4,5-c]quinolines, 6,7,8,9-tetrahydroimidazo[4,5-c]quinolines, imidazo[4,5-c]naphthyridines, and 6,7,8,9-tetrahydroimidazo[4,5-c]naphthyridines) with a -CH(-X1-R1)-group in the fused ring at the 1-position of the imidazo ring, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

L'invention concerne des composés à cycle [1,2]imidazo[4,5-c] fusionné (tels que des imidazo[4,5-c]quinolines, des 6,7,8,9-tétrahydroimidazo[4,5-c]quinolines, des imidazo[4,5-c]naphtyridines et des 6,7,8,9-tétrahydroimidazo[4,5-c]naphtyridines) avec un groupe -CH(-X1-R1)- dans le cycle fusionné en position 1- du cycle imidazo, des compositions pharmaceutiques contenant ces composés, des produits intermédiaires, des méthodes destinées à la fabrication de ces composés, ainsi que des méthodes dans lesquelles ces composés sont utilisés comme immunomodulateurs pour induire la biosynthèse de cytokines chez des animaux et pour traiter des maladies, y compris des maladies virales et néoplasiques.

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