Chiral gultarate esters, their resolution and derived...

C - Chemistry – Metallurgy – 12 – P

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C12P 41/00 (2006.01) C07C 69/608 (2006.01) C07C 69/612 (2006.01) C07D 213/55 (2006.01) C07D 401/04 (2006.01) C12N 1/14 (2006.01) C12P 7/44 (2006.01) C12P 17/12 (2006.01) C12P 17/16 (2006.01)

Patent

CA 2116108

2116108 9304058 PCTABS00020 Enantiomers of chiral compounds such as 3-ethyl-3-(4-pyridyl)piperidine-2,6-dione (Rogletimide) are prepared by cyclising the corresponding diesters such as diethyl 2-ethyl-2-(4-pyridyl)glutarate which themselves are prepared by enantiospecific biotransformation of the racemic diester.

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