Chiral heptyne derivatives for the preparation of...

C - Chemistry – Metallurgy – 07 – D

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C07D 309/10 (2006.01)

Patent

CA 2560455

The invention relates to a new synthetic process for the production of key intermediates useful in the synthesis of epothilones or epothilone derivatives, to certain compounds used to produce these key intermediates and to a process to produce said compounds. The intermediates used are represented by formulae II and III, wherein R is selected from H, alkyl and substituded alkyl and X1 is an oxygen protecting group.

Cette invention concerne un nouveau procédé de synthèse permettant de produire des produits intermédiaires clés utiles dans la synthèse des épothilones et des dérivés d'épothilones. Cette invention concerne également certains composés utilisés pour produire ces produits intermédiaires clés, ainsi qu'un procédé permettant de produire ces composés. Les produits intermédiaires sont représentés par les formules II et III; dans ces formules, R est choisi dans le groupe comprenant H, alkyle et alkyle substitué et X¿1? représente un groupe de protection oxygène.

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