Chirale oxazole-arylpropionic acid derivatives and their use...

C - Chemistry – Metallurgy – 07 – D

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C07D 263/32 (2006.01) A61K 31/421 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2499721

The present invention relates to compounds of Formula (I), wherein R1 to R6 and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment and/or prevention of diseases, which are modulated by PPAR.alpha. and/or PPAR.gamma. agonists as e.g. type II diabetes.

L'invention concerne des composés représentés par la formule (I) et les sels et esters pharmaceutiquement acceptables desdits dérivés. Dans ladite formule, R?1¿ à R?6¿ et n sont tels que définis dans le descriptif et les revendications. Ces composés sont utiles pour le traitement et/ou la prévention de maladies qui sont modulées par les agonistes de PPAR? et/ou de PPAR?, par exemple le diabète de type II.

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