Chirally enriched synthetic phosphonate oligomers

Details Chirally enriched synthetic phosphonate oligomers Chirally enriched synthetic phosphonate oligomers

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2176372

Oligomers having phosphonate internucle- osidyl linkages which are enriched for phosphonate linkages of a preselected chirality which hybridize to an RNA target sequence and methods for their preparation are provided.

Oligomères présentant des liaisons internucléosidyle phosphonate, enrichis en liaisons phosphonate de chiralité présélectionnée et s'hybridant à une séquence d'ARN cible, ainsi que leurs procédés de préparation.

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