Chitosan-based colloidal particles for rna delivery

Details Chitosan-based colloidal particles for rna delivery Chitosan-based colloidal particles for rna delivery

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) A61K 47/24 (2006.01) A61K 47/36 (2006.01) A61K 48/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) A61K 31/7105 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2675378

The present invention provides new colloidal particles of negative zeta potential comprising a ribonucleic acid, a chitosan and a polyanion, and compositions comprising such particles. The compositions are useful for delivery of ribonucleic acids into mammalian cells i n vitro , ex vivo and in vivo.

La présente invention propose de nouvelles particules colloïdales de potentiel zéta négatif qui comprennent un acide ribonucléique, un chitosane et un polyanion, et des compositions comprenant ces particules. Les compositions sont utiles pour la délivrance d'acides ribonucléiques dans des cellules mammifères in vitro, ex vivo et in vivo.

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