Chk1 suppresses a caspase-2 apoptotic response to dna damage...

Details Chk1 suppresses a caspase-2 apoptotic response to dna damage... Chk1 suppresses a caspase-2 apoptotic response to dna damage...

C - Chemistry, Metallurgy

12

Q

C12Q 1/37 (2006.01) A61K 49/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2714003

The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or radiotherapy. Methods for screening candidates for a Chk1 inhibitor- based cancer treatment regimen are also described.

L'invention porte sur des procédés de traitement du cancer qui consistent à administrer un inhibiteur de Chk1 qui est capable d'induire l'apoptose dans des cellules déficientes en p53 lorsqu'il est combiné à une chimiothérapie et/ou une radiothérapie. L'invention concerne également des procédés qui permettent de cribler des candidats d'un régime thérapeutique anticancéreux à base d'inhibiteurs de Chk1.

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