Chlamydia antigens and corresponding dna fragments and uses...

Details Chlamydia antigens and corresponding dna fragments and uses... Chlamydia antigens and corresponding dna fragments and uses...

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) A61K 39/118 (2006.01) A61K 48/00 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2348747

In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequence encoding a 98 kDa outer membrane protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the 98kDa outer membrane protein gene in the host. Modifications are possible within the scope of this invention.

Succinctement, cette invention concerne une technique d'immunisation par acide nucléique (dont l'ADN) d'un hôte, homme y compris, contre des maladies dues à une infection par une souche de Chlamydia, plus particulièrement de C. pneumoniae. Cette technique fait intervenir un vecteur qui renferme une séquence nucléotidique codant pour une protéine de membrane externe de 98 kDa d'une souche de Chlamydia pneumoniae et un promoteur pour permettre l'expression d'un gène de la protéine de membrane extérieure de 98kDa chez l'hôte. Certaines modifications sont possibles dans le cadre de cette invention.

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