C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 31/713 (2006.01) A61K 39/118 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2341637
In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequence encoding any of the following polypeptides: CPN 100111, CPN 100224, CPN 100230, CPN 100231, CPN 100232, CPN 100235, CPN 100394, CPN 100395 of a strain of Chlamydia pneumoniae and a promoter to effect expression of any of the polypeptides in the host. Modifications are possible within the scope of this invention.
La présente invention concerne essentiellement un procédé mettant en oeuvre un acide nucléique, et notamment de l'ADN, pour immuniser un hôte tel qu'un humain contre des affections imputables à une souche de Chlamydia, et plus particulièrement de C. pneumoniae. On utilise à cet effet un vecteur contenant une séquence de nucléotides codant l'un quelconque des polypeptides tels que les CPN 100111, CPN 100224, CPN 100230, CPN 100231, CPN 100232, CPN 100235, CPN 100394 et CPN 100395 d'une souche de Chlamydia pneumoniae. L'invention concerne également un promoteur capable de réaliser l'expression chez l'hôte de l'un quelconque de ces polypeptides. Des modifications restent possible dans les limites des intentions de cette invention.
Murdin Andrew D.
Oomen Raymond P.
Connaught Laboratories Limited
Mbm Intellectual Property Law Llp
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